Beijing, Shanghai, Boston, Mar 15, 2023—Jacobin Pharma (1167.HK) today announced that the company will present the results of three preclinical studies of KRAS^multi inhibitor JAB-23425, CD73-STING iADC JAB-X1800, and Aurora kinase A inhibitor JAB-2485 in form of the abstract during the American Association for Cancer Research (AACR) Annual Meeting 2023 (the “AACR 2023”) from April 14 to 19, 2023.

Details for the 2023 AACR abstracts are as follows:

Abstract Number:1660
Abstract Title: Preclinical investigation of orally bioavailable, potent KRAS^multi inhibitor JAB-23425
Session : Novel Antitumor Agents 4
Time : April 17, 2023, 9 :00 AM – 12 :30 PM (ET)

KRAS^multi inhibitor JAB-23425 targets multiple KRAS mutants in both RAS(ON) and RAS (OFF), with good selectivity over HRAS and NRAS. JAB-23425 has significant antitumor effect on cancer models with multiple KRAS mutations (such as G12D, G12V, and G13D) and amplification of wild type KRAS, and has no inhibitory effect on KRAS-independent cells. The KRAS^multi inhibitor JAB-23425 is expected to solve the unmet clinical needs of patients with KRAS-mutated tumors. JAB-23425 is a leading compound of Jacobio’s KRAS^multi inhibitor.
https://www.abstractsonline.com/pp8/#!/10828/presentation/6635

Abstract Number: 2923
Abstract Title: JAB-X1800: a potent immunostimulatory antibody-drug conjugate (iADC) targeting CD73
Session: Therapeutic Antibodies 2
Time: April 17, 2023, 1:30 PM – 5:00 PM (ET)

JAB-X1800 is the world's first iADC by conjugating Jacobio’s STING agonist to CD73 antibody, which is expected to turn the tumor from “cold” to “hot,” and combine synergize with anti-PD-1 mAb.
https://www.abstractsonline.com/pp8/#!/10828/presentation/3620

Abstract Number: 1645
Abstract Title: JAB-2485: a potent, highly selective small-molecule Aurora kinase A inhibitor that targets cell division
Session : Novel Antitumor Agents 4
Time : April 17, 2023, 9 :00 AM – 12 :30 PM (ET)

JAB-2485 is one of the top two highly selective Aurora A inhibitor with 1500-fold selectivity over Aurora kinase B and Aurora kinase C, with high activity and low bone marrow toxicity as well as favorable PK properties.
https://www.abstractsonline.com/pp8/#!/10828/presentation/6620

“Jacobio leverages our IADDP (Induced Allosteric Drug Discovery Platform) to develop drugs aiming specific undruggable targets,” said Dr. WANG Yinxiang, chairman and CEO of Jacobio, “These preclinical data are part of the research and development achievements of Jacobio since its establishment 8 years ago, and we will continue to transform the fundamental research in academia into clinical achievements through independent R&D in the future."

The 2023 AACR Annual Meeting will be held in Orlando, Florida, USA from April 14th to April 19th. For more information, please visit the official website of the AACR: https://www.aacr.org/meeting/aacr-annual-meeting-2023/

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