Beijing, Shanghai, Boston, Dec.2, 2022—Jacobio Pharma (1167.HK) will present the results of KRAS G12C inhibitor JAB-21822 as a single agent or in combination with SHP2 inhibitor JAB-3312 in preclinical cancer models in a poster session during the 2022 European Society of Medical Oncology ASIA (ESMO ASIA) Congress from December 2, 2022 to December 4, 2022.

The results of preclinical study showed that JAB-21822 in combination with JAB-3312 could synergistically inhibit tumor growth in multiple KRAS G12C inhibitor-resistant models, suggesting that the combination of JAB-21822 and JAB-3312 may overcome adaptive resistance to KRAS G12C inhibitor in cancer patients. Jacobio is currently conducting a clinical trial of JAB-21822 in combination with JAB-3312 (ClinicalTrials.gov Identifier: NCT05288205).

About the Abstract:
Track: Developmental therapeutics
Title: Investigation of KRAS G12C inhibitor JAB-21822 as a single agent and in combination with SHP2 inhibitor JAB-3312 in preclinical cancer models
Format: Poster presentation
Abstract Number: 30P
Time: December 3, 2022
Please visit the official website of ESMO ASIA for more information: https://www.esmo.org/meeting-calendar/esmo-asia-congress-2022

About JAB-21822
JAB-21822 is an oral, small molecule KRAS G12C inhibitor independently developed by the Company. The Company has initiated a number of Phase I/II clinical trials in China, the United States and Europe for patients harbouring KRAS G12C mutation with advanced solid tumors, including pivotal clinical trial to treat non-small cell lung cancer in China; monotherapy for STK11 co-mutated non-small cell lung cancer in the front-line setting; combination therapy with SHP2 inhibitor JAB-3312, anti-PD-1 monoclonal antibody and cetuximab.

About JAB-3312
JAB-3312 is a high-selective SHP2 allosteric inhibitor. Jacobio is currently conducting clinical trials of JAB-3312 in China and the United States, and JAB-3312 has been granted orphan drug designation for esophageal cancer (including esophageal squamous cell carcinoma) by the U.S. Food and Drug Administration (FDA). Jacobio has signed a global, strategic collaboration agreement to develop and commercialise SHP2 inhibitors with AbbVie on June 1, 2020.

About Jacobio